Applied ML in Healthcare
Identifying and Characterizing Asthma Subgroups at High Risk of Severe Exacerbations with Machine Learning and Longitudinal Real-World Data
Dual supervised/unsupervised ML approach using real-world claims data to predict acute exacerbation and identify acute exacerbation risk subgroups among asthma patients
Automated Clinical Concept Mapping Using SNOMED
Novel system for automatically mapping clinical concepts using SNOMED CT, reducing manual coding overhead and improving data standardization across healthcare systems.
Machine learning using longitudinal prescription and medical claims for the detection of nonalcoholic steatohepatitis (NASH)
Machine learning approach using prescription and medical claims data to detect NASH patients, demonstrating early identification capabilities before traditional diagnostic methods.
Using SNOMED to automate clinical concept mapping
Novel NLP graph-traversal algorithm for ICD edition mapping using SNOMED to support health data interoperability.
AI Plus Real-World Data for Early Prediction of Disease Progression and Operationalized Precision Targeting
Framework for combining AI with real-world data to enable early disease progression prediction and operationalized precision targeting for improved patient outcomes.
Unbiased ETL System For Timed Medical Event Prediction
Patent-pending ETL system designed to minimize temporal bias in medical event prediction models.
Neuroscience & Cancer Research
Loss of oligodendrocyte ErbB receptor signaling leads to hypomyelination, reduced density of parvalbumin‐expressing interneurons, and inhibitory function in the auditory cortex
Investigation of how mild hypomyelination due to loss of oligodendrocyte ErbB receptor signaling affects both excitatory and inhibitory connectivity in primary auditory cortex.
Exposure to enriched environment rescues anxiety-like behavior and miRNA deregulated expression induced by perinatal malnutrition while altering oligodendrocyte morphology
Study showing how enriched environments can rescue anxiety behaviors caused by perinatal malnutrition through modulation of miRNAs and oligodendrocyte morphology changes.
Myelin development, plasticity, and pathology in the auditory system
Comprehensive review of myelin's role in auditory system development, examining how myelin plasticity contributes to normal function and pathological changes affect hearing.
Acetate supplementation as a means of inducing glioblastoma stem‐like cell growth arrest
Investigation of acetate supplementation as a therapeutic approach for inducing growth arrest in glioblastoma stem-like cells, offering potential cancer treatment strategies.
Triacetin‐based acetate supplementation as a chemotherapeutic adjuvant therapy in glioma
Development of triacetin-based acetate supplementation as adjuvant chemotherapy for glioma treatment, demonstrating enhanced therapeutic efficacy in cancer models.
Dynamic regulation of myelination in health and disease
Analysis of dynamic myelination processes and their regulation in both healthy brain function and psychiatric diseases, highlighting therapeutic implications.
To learn is to myelinate
Perspective examining the relationship between learning processes and myelination, challenging traditional views of brain plasticity by highlighting oligodendrocyte roles in learning.
N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) promote growth and inhibit differentiation of glioma stem-like cells
Study of NAA and NAAG metabolites in glioma stem cell growth, advising against their use to affect acetate bioavailability in glioma.
Acetate supplementation induces growth arrest of NG2/PDGFRα-positive oligodendroglioma-derived tumor-initiating cells
Demonstration that acetate supplementation can induce growth arrest in oligodendroglioma-derived tumor-initiating cells, offering therapeutic potential for brain tumors.
Differential aminoacylase expression in neuroblastoma
Analysis of aminoacylase expression patterns in neuroblastoma, identifying potential biomarkers and therapeutic targets for pediatric cancer treatment.
Tauopathy with paired helical filaments in an aged chimpanzee
First documentation of Alzheimer's-like tauopathy with paired helical filaments in an aged chimpanzee, providing insights into evolutionary aspects of neurodegenerative diseases.